Pharmacokinetic Assessment of Vancomycin Loading Dose in Critically Ill Patients
نویسندگان
چکیده
منابع مشابه
Necessity of a loading dose when using vancomycin in critically ill patients.
Sir, We are interested in the question of the need for a loading dose in critically ill patients receiving vancomycin. Soto et al. found that standard vancomycin doses of 500 mg (7.5 mg/kg) every 6 h are subtherapeutic in critically ill patients during the first 24–48 h. Since vancomycin is a concentration-independent antibiotic with time above the antimicrobial MIC being the best predictor of ...
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Colistin is an old antibiotic that has recently gained a considerable renewal of interest as the last-line defense therapy against multidrug-resistant Gram-negative bacteria. It is administered as colistin methanesulfonate (CMS), an inactive prodrug, and it was shown that due to slow CMS conversion, colistin plasma concentrations increase very slowly after treatment initiation, which constitute...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2017
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00280-17